Single Particle Extinction and Scattering

SPES (Single Particle Extinction and Scattering) is an innovative patented technology for the characterization of micro and nano particles in fluids. SPES and dedicated data analysis algorithms provide more reliable and meaningful information, boosting R&D – QC processes, during lab scale design and industrial production of particles.

SPES provides more independent parameters for each single measured particle, allowing to: i) distinguish particles of different composition, ii) determine actual size distributions, iii) retrieve information about shape/aspect ratio, iv) control stability/wettability, v) monitor the presence of and characterize aggregates and vi) characterize the contaminants and process scraps in fluids.

SPES distinguishes between particles and components of complex biological, industrial or environmental fluids, including blood, urine, etc. It opens new opportunities, such as i) the characterization of particles in the context where they are supposed to operate, ii) the possibility to measure them despite the presence of synthesis residues allowing a quality control without intermediate steps, and iii) the detection and data rejection from results of possible gas bubbles.

SPES analysis can be performed in-line so to i) adjust processes parameters in real-time on the base of particles characteristics, ii) reduce process time and iii) increase synthesis yield.

 

How Does SPES Work in Brief?

Micro and nanoparticles are driven through a flow cell where a laser beam is focused. For each single enlightened particle, SPES measures simultaneously two independent parameters, i.e. the real and the imaginary components of the scattered field. From a statistically meaningful number of measured particles, SPES creates a 2D histograms of the two measured optical parameters. In few words, SPES creates a map which is the optical fingerprint of the sample.Samples with different size distribution, composition, refractive index, structure, aggregation state, wetting, shape and/or surface resonance plasmon create different optical fingerprints. And samples with heterogeneous composition produce simultaneously more optical fingerprints on the same map, one for each component.
Thanks to EOS proprietary algorithms and specific data analysis, SPES separates and classifies the different optical fingerprints, allowing to obtain novel and valuable information on the samples that are foreclosed to traditional particle sizing technologies.

EOS boosts innovation through SPES! We provide standard solutions and Technology Trasnfer Services to revolutionize your products developoment, formulation and promote effective quality controls of micro and nanoparticles in biological, industrial and environmental complex fluids.