Structural studies

Structural studies of subvisible/submicron particles include the analysis of their internal structure as well as the evolution of their shape and degradation over time. These characteristics may or may not be evident by the sole particles size distribution. The capability of the patented SPES technology to retrieve at least two parameters for each analysed particle, together with EOS proprietary algorithms and specific data analysis, allows to compare characteristics of sample even with a similar size distribution. SPES technology opens the development of novel products in a wide range of applications!

  • evidence of active principle encapsulation in drug delivery systems
  • analysis of internal structure for micro/nanocapsules and liposomes
  • monitoring of the particle aggregation or flocculation
  • evolution of particles degradation over time
  • characterization of particles with no spherical shape


Application Ground Materia_particleslSPES determines shape and size distributions of polydisperse micron-sized particles. A rough estimation of the sample refractive index is sufficient for enabling SPES to give information on the Aspect Ratio particle Distribution (ARD) and the Equivalent Diameter Distribution (EDD) of microparticles. Reduced a priori knowledge on the sample is request with respect to traditional methods. Moreover, valuable sample characteristics are quickly and easy obtained without the support of commonly needed expensive and time-consuming analysis, e.g. with electron microscopy.


Application Gold_particle image

For defined materials such as gold and silver nanoparticles, SPES classifies particles with different surface shap and roughness! Find out how!


SPES discriminates and characterizes particles with different internal structure as:

  • core-shell capsules
  • particles with proteins, drugs or molecules loaded
  • inclusions
  • particles under degradation

TechStructural00Improve the performance, processability, stability and appearance of your end product, as well as its dissolution and absorption rates, and content uniformity!


SPES monitors and characterizes the presence or formation of particle clusters, flocs, or aggregates. Aggregates compactness and size can be measured. Take advantage of thisunique capabilityfor the improvement of yourformulation processes:monitor andextendyour product shelf life or look for its stability when in contact with the complex medium/mixture where it has to be employed.