Particle Structural studies

Structural studies of subvisible/submicron particles include the analysis of particle structure, of the evolution of their shape, and of the particle behaviour and degradation over time. These characteristics may or may not be evident by the particle size distribution alone. The multiparametric patented SPES technology and EOS proprietary algorithms allow to identify and get insights on characteristics of samples with a similar size distribution but different optical properties:

  • evidence of encapsulation of API and inclusions in delivery systems.
  • analysis of capsules and mesoporous particles.
  • monitor of the particle aggregation and flocculation.
  • study of the evolution of particle degradation, wetting and oversize.
  • characterization of particles with non-spherical shape.


Application Ground Materia_particleslSPES classifies shapes and size distributions of nonpherical particles. Thanks to the estimation of the effective refractive index, SPES provides insights on the Aspect Ratio particle Distribution (ARD) and the Equivalent Diameter Distribution (EDD) of non-spherical particles of know formulation. Less a priori knowledge on the sample is request with respect to traditional methods.



Application Gold_particle image
Moreover, for defined materials such as gold, silver, and platinum particles, SPES classifies particles with different surface shape and roughness taking advantage of the plasmon surface resonances! Find out how!


SPES discriminates and characterises particles with different internal structure as:

  • core-shell capsules
  • particles with API
  • particles with inclusions
  • mesoporous systems
  • particles under degradation

ImTechStructural00prove the performance, processability, stability, and appearance of final formulation, as well as product dissolution and absorption rates, and content uniformity!


SPES monitors and characterizes the presence or the formation of particle clusters, flocs, and aggregates thanks to their difference in effective refractive index respect to bulk material and well-dispersed particles. Information on aggregates compactness and size are provided. Take advantage of this unique capability the formulation and analysis of your products: monitor and extend the product shelf life, improve formulation stability in target complex medium/mixture.